High blood pressure in people ages 12 years and older
Guanfacine is an alpha-2 agonist. It works by binding (attaching) to alpha-2 receptors in the brain. This lowers the amount of norepinephrine, a chemical that normally raises your blood pressure by squeezing your blood vessels.
The typical recommended dose is 1 mg by mouth once a day at bedtime. If needed, your provider might raise your dose after 3 to 4 weeks. The maximum recommended dose is 2 mg once a day.
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